Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | monocytic leukemia |
| ICD-0-3 | M9860/3 |
| Methods | qPCR, Western blot |
| Sample | leukemia cell lines (U-937 (catalog no. TCHu159), THP-1 (catalog no. TCHu 57)) |
| Expression Pattern | up-regulated |
| Function Description | Taken together, these findings suggest that high MALAT-1 expression is closely associated with poor prognosis in M5 patients and may play a role in leukemia cell proliferation and apoptosis, and may serve as a promising theranostic marker. We found that MALAT-1 expression in patients with acute monocytic leukemia (M5) was significantly increased when compared with that of healthy controls, and the overall survival of M5 patients with high MALAT-1 expression was markedly reduced when compared with the overall survival of patients with low MALAT-1 expression. MALAT-1 knockdown was found to induce upregulated protein expression of cyclin E and cyclin-dependent kinase 2 (CDK2) by silencing tumor suppressor gene p53 and activating transcription factor E2F, as a consequence of G1/S phase transition to G2 phase (29). |
| Pubmed ID | 28713913 |
| Year | 2017 |
| Title | Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for monocytic leukemia | Omim Cosmic |
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