Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder transitional cell carcinoma |
| ICD-0-3 | M8120/3 |
| Methods | qPCR, Western blot etc. |
| Sample | cell line (T24, BIU-87, HEK, 293T), bladder tissue |
| Expression Pattern | up-regulated |
| Function Description | The effects of MALAT1 on BTCC cells were investigated by over-expression approaches in vitro and in vivo.Insights of the mechanism of competitive endogenous RNAs (ceRNAs) were validated through bioinformatic analysis and luciferase assay. MALAT1 up-regulation positively correlated with advanced clinical pathological stage and shorter survival of BTCC patients. Furthermore, MALAT1 over-expression promoted proliferation,migration and invasion of BTCC cells in vitro and in vivo. Particularly, MALAT1 may function as a ceRNA to sponge miR-124,thus modulating the derepression of foxq1, miR-124 target gene,in post-transcriptional levels. |
| Pubmed ID | 29736319 |
| Year | 2018 |
| Title | LncRNA MALAT1 promotes tumor growth and metastasis by targeting miR-124/foxq1 in bladder transitional cell carcinoma (BTCC). |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder transitional cell carcinoma | Omim Cosmic |
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