Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | endometrioid endometrial cancer |
| ICD-0-3 | M8930/0 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | EEC tissues, cell lines (RL-952, HEC-1-B and JEC) |
| Expression Pattern | down-regulated |
| Function Description | In the present study, we first showed that miR-200c levels were higher in most EEC specimens than in non-tumor tissues, while MALAT1 levels were lower. Moreover, we found that miR-200c bound directly to MALAT1 using luciferase reporter and qRT-PCR assays. MALAT1 and miR-200c are reciprocally repressed, and TGF-B increased MALAT1 expression by inhibiting miR-200c. When the interaction between miR-200c/MALAT1 was interrupted, the invasive capacity of EEC cells was decreased and EMT markers expression were altered in vitro. |
| Pubmed ID | 27693631 |
| Year | 2016 |
| Title | Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for endometrioid endometrial cancer | Omim Cosmic |
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