Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hilar cholangiocarcinoma |
| ICD-0-3 | M8160/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | HCCA tissues, cell lines (HIBEpiC, RBE, HUH28, FRH0201, QBC939, SNU-1196) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-MALAT1 was specifically upregulated in HCCA tissues and cell lines,and was associated with pathological T stage, a larger tumor size and perineural invasion. Knockdown of MALAT1 inhibited the proliferation, migration and invasion of human HCCA cell. In addition, chemokine receptor-4 (CXCR4) was involved in MALAT1 induced human HCCA growth, migration and invasion. |
| Pubmed ID | 28059437 |
| Year | 2017 |
| Title | Long Non-Coding RNA MALAT1 Interacted with miR-204 to Modulates Human Hilar Cholangiocarcinoma Proliferation, Migration and Invasion by Targeting CXCR4. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for hilar cholangiocarcinoma | Omim Cosmic |
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