Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | tongue squamous cell carcinoma |
| ICD-0-3 | C02 M8070/3 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | TSCC tissues, cell lines (CAL 27 and SCC-25) |
| Expression Pattern | up-regulated |
| Function Description | Expression of MALAT-1 lncRNA was enhanced in TSCCs, especially in those with lymph node metastasis (LNM). Knockdown (KD) of MALAT-1 lncRNA in TSCC cells led to impaired migration and proliferation ability in-vitro and fewer metastases in-vivo. |
| Pubmed ID | 27586393 |
| Year | 2016 |
| Title | Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for tongue squamous cell carcinoma | Omim Cosmic |
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