Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell line (HNEpC, 5-8F, CNE-2, C666-1, HONE-1) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 and Capn4 were upregulated while miR-124 expression was downregulated in NPC cell lines.MALAT1 knockdown inhibited proliferation, invasion and EMT of NPC cells. Moreover, MALAT1 improved Capn4 expression by sponging miR-124. MALAT1 upregulation abated miR-124-induced repression on NPC cell proliferation, invasion and EMT. Furthermore, Capn4 overexpression reversed the inhibitory effect of MALAT1 silencing on proliferation, invasion and EMT of NPC cells. |
| Pubmed ID | 28857668 |
| Year | 2017 |
| Title | MALAT1/miR-124/Capn4 axis regulates proliferation, invasion and EMT in nasopharyngeal carcinoma cells |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for nasopharyngeal cancer | Omim Cosmic |
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