Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (HCT116 and RKO), CRC tissue |
| Expression Pattern | down-regulated |
| Function Description | MALAT1 exerts a modulatory effect on pro-migratory markers such as epithelial cell adhesion molecule (EpCAM) and integrin B 4 (ITGB4),suggesting a potential mechanism for MALAT1-mediated regulation of tumorigenesis.In summary, we establish and characterize a PTEN-miRNA-MALAT1 axis that regulates migration and invasion. MALAT1 lncRNA possesses novel tumor suppressive properties in colon and breast cancers.MALAT1 is regulated by the PTEN-targeting microRNAs miR-17,20a and 106b. |
| Pubmed ID | 29574704 |
| Year | 2018 |
| Title | A non-canonical tumor suppressive role for the long non-coding RNA MALAT1 in colon and breast cancers. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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