Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (T24, 5637) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 is capable of suppressing mature miR-125b and increasing the expression of its target genes (Bcl-2 and MMP-13), but has no effect on pri-miR-125b and pre-miR-125b.We observe that the biotin-labeled MALAT1â??RNA probe is able to pull down Ago2 and miR-125b and that the negative regulation of miR-125b by MALAT1 is dependent on Ago2. Importantly, the results of flow cytometry assay and transwell assay reveal that the MALAT1-mediated cancer progression is in part due to specific suppression of miR-125b and activation of its two target genes. All together, these data suggest that the â??MALAT1-miR-125b-Bcl-2 / MMP-13â?? axis plays an important role in the progression of BCa, thereby may provide a potential therapeutic strategy for the treatment of human BCa. |
| Pubmed ID | 29151968 |
| Year | 2017 |
| Title | LncRNA MALAT1 Inhibits Apoptosis and Promotes Invasion by Antagonizing miR-125b in Bladder Cancer Cells |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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