Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Western blot etc. |
| Sample | cell lines (A549 and A549/DDP) |
| Expression Pattern | up-regulated |
| Function Description | MALAT1 was upregulated in DDP-resistant A549 cell line.MALAT1 decreased DDP sensitivity in vitro and in vivo by upregulating MRP1 and MDR1 via STAT3 activation.Overexpression of MALAT1 contributed to the DDP resistance and might confer a potently poor prognosis. |
| Pubmed ID | 29505924 |
| Year | 2018 |
| Title | LncRNA-MALAT1 contributes to the cisplatin-resistance of lung cancer by upregulating MRP1 and MDR1 via STAT3 activation. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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