Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, ChIP, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | bladder urothelial carcinoma tissues, cell lines (T24, 5737, SV-HUC-1, HEK 293T) |
| Expression Pattern | up-regulated |
| Function Description | Hsa-miR-125b was down-regulated in bladder cancer compared with matched normal urothelium. Both SIRT7 and MALAT1 were up-regulated in bladder cancer compared with matched normal urothelium. Upregulation of hsa-miR-125b or downregulation of SIRT7 inhibited proliferation, motility and increased apoptosis. |
| Pubmed ID | 24512851 |
| Year | 2013 |
| Title | Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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