Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, RNAi etc. |
| Sample | ESCC tissues, cell lines (TE1, KYSE30, KYSE70, KYSE150, KYSE270, KYSE410, EC9706) |
| Expression Pattern | up-regulated |
| Function Description | Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase |
| Pubmed ID | 26493997 |
| Year | 2015 |
| Title | Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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