Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, RNAi |
| Sample | cell lines (MNNG/HOS) |
| Expression Pattern | differential expression |
| Function Description | MALAT1 plays an important role in OS progression by modulating the enhancers of zeste homolog 2 (EZH2).MALAT1 could inhibit the expression of E-cadherin and promote the expression of B-catenin, and tthis phenomenon might be the outcome of MALAT1-induced EZH2 activation. MALAT1 silencing using small interfering RNAs (siRNAs), the loss of E-cadherin of MNNG/HOS cells was rescued, and the abnormal expression and localization of B-catenin were corrected at the same time.The MALAT1/EZH2 axis participates in OS cell proliferation, migration, and cell survival in vitro. |
| Pubmed ID | 29290771 |
| Year | 2018 |
| Title | Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of B-catenin. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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