Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Cell transfection, Western blot, Dual-luciferase reporter assay, Flow cytometry assay etc. |
| Sample | cell lines (SiHa and CaSki) |
| Expression Pattern | differential expression |
| Function Description | MiR-375 overexpression or MALAT1 siRNA partly restored E-cadherin expression and also significantly reduced N-cadherin. Following immunofluorescent staining confirmed these trends. Since EMT is an important mechanism of enhanced tumor cell invasion and metastasis, we further detected how miR-375 and MALAT1 modulate invasion capacity of SiHa cells. Transwell assay showed that both miR-375 overexpression and MALAT1 knockdown significantly reduced invasion capacity of SiHa cells. |
| Pubmed ID | 27658300 |
| Year | 2016 |
| Title | MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.