Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay, Immunofluorescent assay etc. |
| Sample | cell lines (HBL-100, MCF-7, MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | In this study we identified long non-coding RNA (lncRNA) MALAT1 can function as a ceRNA of cell division cycle 42 (cdc42) 3'UTR in inducing migration and invasion of breast cancer cells via miR-1. We found that miR-1 bound both MALAT1 and cdc42 3'UTR directly. Further study showed that MALAT1 induced migration and invasion of breast cancer cells while reduced the level of cdc42. |
| Pubmed ID | 26926567 |
| Year | 2016 |
| Title | MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42 |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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