Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | gastric cancer tissues, cell lines (MKN45, MKN28, BGC-823, and SGC-7901) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we demonstrated MALAT1 was up-regulation in GC tissues compared with adjacent normal tissues and higher MALAT1 expression was correlated with local invasion, lymph node metastasis and TNM stage. Patients with higher MALAT1 expression predicted a shorter survival and poor prognosis. Mechanistically, our results demonstrated that MALAT1 was negatively correlation with miR-1297 and functioned as a molecular sponging miR-1297, antagonizing its ability to suppress HMGB2 expression. |
| Pubmed ID | 28396617 |
| Year | 2017 |
| Title | Long non-coding RNA MALAT1 drives gastric cancer progression by regulating HMGB2 modulating the miR-1297 |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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