Detail
| LncRNA Name | ASBEL |
| Synonyms | BTG3-AS1 |
| Region | GRCh38_21:17611744-17633199 Sequence |
| Ensembl | ENSG00000280594 |
| RefSeq | NR_149073 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qRT-PCR, Western blot, in vitro knockdown |
| Sample | osteoblast cell line hFOB1.19 and human osteosarcoma cell line MG63, osteosarcoma cell line OS-732 |
| Expression Pattern | up-regulated |
| Function Description | ASBEL was highly expressed in osteosarcoma cells. Knockdown of ASBEL inhibited osteosarcoma cell viability, migration, and invasion, as well as the expression level of miR-21. PP2A was a direct target of miR-21, which participated in the effects of ASBEL and miR-21 on the activation of phosphatidylinositol 3-kinase/protein kinase 3/glycogen synthase kinase-3B (PI3K/AKT/GSK3B) and mitogen-activated protein kinase/extracellular regulated protein kinase (MEK/ERK) signaling pathways as well as the enhancement of osteosarcoma cell proliferation, migration, and invasion. |
| Pubmed ID | 29323740 |
| Year | 2018 |
| Title | Long non-coding RNA ASBEL promotes osteosarcoma cell proliferation, migration, and invasion by regulating microRNA-21. |
| External Links |
| Links for ASBEL | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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