Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | gastric cancer tissues, cell lines (SGC-7901, BGC823, AGS and MKN45) |
| Expression Pattern | up-regulated |
| Function Description | MALAT-1 was upregulated in GC cell lines and tissues. Moreover, MALAT-1 expression was higher in the high-metastatic-potential GC cell line SGC7901M than in the low-metastatic-potential GC cell line SGC7901NM. Silencing of MALAT-1 inhibited GC cell migration and invasion. In addition, suppressing MALAT-1 expression resulted in a decrease in the expression of the Epithelial-mesenchymal transition-associated marker vimentin and an increase in the expression of E-cadherin at both the mRNA and protein levels. |
| Pubmed ID | 28276823 |
| Year | 2017 |
| Title | The role of MALAT-1 in the invasion and metastasis of gastric cancer. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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