Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot, ChIP, Cell proliferation assay etc. |
| Sample | HCC tissues, cell lines (HepG2, SMMC-7721, Bel-7402, MHCC97H, and HCC-LM3) |
| Expression Pattern | up-regulated |
| Function Description | In addition, hypoxia-inducible factor (HIF)-2a is up-regulated in HCCs, and MALAT1 and HIF-2a have a positive correlation in HCC tissues. During the malignant transformation of human hepatic epithelial (L-02) cells induced by a low concentration (2.0 μM) of arsenite, MALAT1 and HIF-2a are increased. In addition, arsenite-induced MALAT1 causes disassociation of the von Hippel-Lindau (VHL) protein from HIF-2a, therefore, alleviating VHL-mediated HIF-2a ubiquitination, which causes HIF-2a accumulation. In turn, HIF-2a transcriptionally regulates MALAT1, thus forming a positive feedback loop to ensure expression of arsenite-induced MALAT1 and HIF-2a, which are involved in malignant transformation. Moreover, MALAT1 and HIF-2a promote the invasive and metastatic capacities of arsenite-induced transformed L-02 cells and in HCC-LM3 cells. |
| Pubmed ID | 26735578 |
| Year | 2016 |
| Title | A MALAT1/HIF-2a feedback loop contributes to arsenite carcinogenesis. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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