Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Western blot, Dual luciferase reporter assays, etc. |
| Sample | NSCLC tissues, cell lines (A549, H1299, BEAS-2B, HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | High expression of MALAT1 correlated positively with tumor size and lymphatic metastasis in NSCLC. MALAT1 promoted cell migration and invasion by sponging miR-206 in NSCLC cells. lncRNA MALAT1 promotes migration and invasion of NSCLC by targeting miR-206 and activating Akt/mTOR signaling. |
| Pubmed ID | 29916897 |
| Year | 2018 |
| Title | LncRNA MALAT1 promotes migration and invasion of non-small-cell lung cancer by targeting miR-206 and activating Akt/mTOR signaling. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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