Detail
| LncRNA Name | MALAT1 |
| Synonyms | MALAT1, HCN, LINC00047, NCRNA00047, NEAT2, PRO2853, PRO1073, MALAT-1, mascRNA |
| Region | GRCh38_11:65497688-65506516 Sequence |
| Ensembl | ENSG00000251562 |
| RefSeq | NR_002819 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP etc. |
| Sample | non small cell lung cancer tissues, cell line (NSCLC A549, NCI-H460, and NCI-H529) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA MALAT-1 expression was higher in NSCLC tissues than that in adjacent tissues, but a lower expression of miR-124 was detected in the former tissues than in the latter tissues. Compared with 16HBE cells, MALAT-1 was highly expressed in NSCLC tissues. Compared with the blank group, E-cadherin and cell apoptosis were increased, but vimentin, cell variability, cell invasion, and migration ability in the si-MALAT-1 and miR-124 mimics groups were reduced. Compared with the blank group, decreased E-cadherin and cell apoptosis and increased vimentin, cell variability, cell invasion, and migration ability were detected in the oe-MALAT-1 group. The oe-MALAT-1+miR-124 mimics group had increased E-cadherin and cell apoptosis, but decreased vimentin, cell variability, cell invasion, and migration ability in comparison with the oe-MALAT-1 group. By competitively regulating miR-124, MALAT-1 can promote epithelial-mesenchymal transition, thus accelerating the development of NSCLC. |
| Pubmed ID | 29782349 |
| Year | 2018 |
| Title | LncRNA MALAT-1 competitively regulates miR-124 to promote EMT and development of non-small-cell lung cancer. |
| External Links |
| Links for MALAT1 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.