Detail
| LncRNA Name | MAP3K20 |
| Synonyms | MLK7, MLTK, MLTKalpha, MLTKbeta, MRK, ZAK |
| Region | GRCh38_2:173075435-173268010 Sequence |
| Ensembl | ENSG00000091436 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP etc. |
| Sample | cell line (HGC27, SGC7901, MGC803, AGS and MKN-45, GES-1), gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | MLK7-AS1 interacted with Dnmt1 and recruited it to miR-375 promotor, hyper-methylating miR-375 promotor and repressing miR-375 expression. Our findings demonstrate that knockdown of MLK7-AS1 by siRNA inhibits gastric cancer growth by epigenetically regulating miR-375. Knockdown of MLK7-AS1 by siRNA increased the expression of miR-375. MiR-375 wasfound to be an important tumor suppressor in gastric cancer bytargeting Janus kinase 2 (JAK2). |
| Pubmed ID | 29428732 |
| Year | 2018 |
| Title | Knockdown of long non-coding RNA MAP3K20 antisense RNA 1 inhibits gastric cancer growth through epigenetically regulating miR-375. |
| External Links |
| Links for MAP3K20 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.