Detail
| LncRNA Name | MBNL3 |
| Synonyms | NA |
| Region | GRCh38_X:132369317-132489968 Sequence |
| Ensembl | ENSG00000076770 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot etc. |
| Sample | HCC tissues, cell lines (QSG-7701, SMMC-7721, HCCLM3, MHCC97H, Huh7, HepG2 and Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | MBNL3 knckdoown almost completely abolishes hepatocellular carcinoma tumorigenesis.Mbnl3 was upregulated in mouse fetal livers compared with adult livers. high MBNL3 protein level in HCC tissues correlated with reduced recurrence-free survival and overall survival.In our previous microarray result of mouse liver development, Mbnl3 was upregulated in mouse fetal livers compared with adult livers.Bioinformatic analysis by Miranda and TargetScan predicted one miR-24 binding site in the 30UTR of PXN mRNA complementary to PXN-AS1-L.Kaplanā??Meier analyses of the correlations between MBNL3 mRNA level and recurrence-free survival or overall survival of n=68 HCC patients. |
| Pubmed ID | 28553938 |
| Year | 2017 |
| Title | The MBNL3 splicing factor promotes hepatocellular carcinoma by increasing PXN expression through the alternative splicing of lncRNA-PXN-AS1. |
| External Links |
| Links for MBNL3 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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