Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | M9861/3 |
| Methods | qPCR |
| Sample | bone marrow |
| Expression Pattern | down-regulated |
| Function Description | MEG3 expression was lower in AML patients than in the controls (P = 0.136). Moreover, there was greater methylation of MEG3 promoter in the AML patients than the controls (P < 0.05). hese results suggest that hypermethylation of the MEG3 promoter in AML may result from decreased TET2 activity. |
| Pubmed ID | 28407691 |
| Year | 2017 |
| Title | TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for acute myeloid leukemia | Omim Cosmic |
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