Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | T-cell lymphoblastic lymphoma |
| ICD-0-3 | M9729/3 |
| Methods | qPCR, Western blot, Luciferase report assay etc. |
| Sample | T-LBL tissues, cell lines (CCRF-CEM, Jurkat, SUP-T1, H9) |
| Expression Pattern | down-regulated |
| Function Description | Down-regulated level of MEG3 was also found in three T-LBL cell lines (CCRF-CEM, Jurkat and SUP-T1) compared with human T-cell line H9. MEG3 worked as an anti-oncogene in T-LBL, and the MEG3-miR-214-AIFM2 pathway regulated the growth of T-LBL, providing potential prognosis markers as well as new potential targets for T-LBL treatment. MEG3 effectively suppressed tumor growth and the expression of proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA). |
| Pubmed ID | 28534937 |
| Year | 2017 |
| Title | The inhibitory effect of MEG3/miR-214/AIFM2 axis on the growth of T-cell lymphoblastic lymphoma. |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for T-cell lymphoblastic lymphoma | Omim Cosmic |
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