Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name MEG3
   Synonyms MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1
   Region GRCh38_14:100779410-100861031    Sequence
   Ensembl ENSG00000214548
   RefSeq NR_002766
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name pituitary adenoma
   ICD-0-3 C75.1  M8272/0
   Methods qPCR etc.
   Sample pituitary tumor tissues
   Expression Pattern down-regulated
   Function Description

In summary, MEG3 and GADD45γ expression was significantly lost in most clinically non-functioning adenomas (78 and 92%, respetcively). Other assessed pituitary tumor phenotypes expressed both genes at significantly different levels, and, in some cases, with overexpression.

   Pubmed ID 21850407
   Year 2012
   Title Expression of cell growth negative regulators MEG3 and GADD45γ is lost in most sporadic human pituitary adenomas.
   External Links
   Links for  MEG3 GenBank       HGNC       lncrnadb       Noncode
   Links for  pituitary adenoma Omim       Cosmic

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