Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | non-functioning pituitary adenoma |
| ICD-0-3 | C75.1 M8272/0 |
| Methods | qPCR etc. |
| Sample | pituitary tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | Maternally Expressed Gene 3 (MEG3), which is specifically associated with clinically non-functioning pituitary adenomas of a gonadotroph lineage. Complimentary DNA-RDA revealed that MEG3 mRNA is present in the normal human pituitary but absent in clinically non-functioning tumors. MEG3 functions to suppress tumor cell growth, increase protein expression of the tumor suppressor p53, and selectively activate p53 target genes. Interestingly, MEG3 does not encode a protein but a non-coding RNA. |
| Pubmed ID | 20211686 |
| Year | 2010 |
| Title | Isolation and characterization of novel pituitary tumor related genes: a cDNA representational difference approach. |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for non-functioning pituitary adenoma | Omim Cosmic |
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