Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | glioma tumors, cell lines (U251, U87 and A172) |
| Expression Pattern | down-regulated |
| Function Description | The levels of MEG3 expression were significantly decreased in glioma tissues compared with normal brain tissues. We found marked downregulation in high-grade glioma samples and to a lesser degree, decreased in low-grade glioma samples, as compared to normal brain tissues, which gave clues that MEG3 may be involved in the disease pathogenesis in glioma |
| Pubmed ID | 26676363 |
| Year | 2016 |
| Title | Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas. |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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