Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (RKO, SW1116, HT29, HCT116,LoVo, SW620, SW480, 293 T), CRC tissue |
| Expression Pattern | down-regulated |
| Function Description | MEG3 was down-regulated in CRC tissues and CRC patients with lower MEG3 showed poorer overall survival and disease-free survival than those with higher MEG3 level.MEG3 over-expression represses CRC cells proliferation and migration in vivo and in vitro,while MEG3 knockdown leads to the enhanced proliferation and metastasis of CRC cells.In CRC cells, MEG3 over-expression is related to decreased Clusterin mRNA and the corresponding protein levels,and it also directly binds to Clusterin protein through its 732-1174 region.In further, Clusterin over-expression rescues the compromised abilities of proliferation and metastasis induced by MEG3 over-expression,suggesting that MEG3 inhibits the CRC progression through regulating the Clusterin activities.Additionally,we found that 1a,25-(OH)2D and vitamin D receptor (VDR) stimulate MEG3 expression in CRC cells through directly binding to its promoter. |
| Pubmed ID | 29628342 |
| Year | 2018 |
| Title | MEG3 Activated by Vitamin D Inhibits Colorectal Cancer Cells Proliferation and Migration via Regulating Clusterin. |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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