Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, Cell transfection, Western blot, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U251, U87, NHA) |
| Expression Pattern | down-regulated |
| Function Description | MEG3 was down-regulated and miR-19a was up-regulated in malignant glioma tissues and cell lines. MiR-19a represses the expression of PTEN and promotes glioma cell proliferation, migration and invasion. However, MEG3 could directly bind to miR-19a and effectively act as a competing endogenous RNA (ceRNA) for miR-19a to suppress tumorigenesis. |
| Pubmed ID | 28276316 |
| Year | 2017 |
| Title | Long Noncoding RNA MEG3 Suppresses Glioma Cell Proliferation, Migration, and Invasion By Acting As Competing Endogenous RNA of MiR-19a. |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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