Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | chronic myeloid leukemia |
| ICD-0-3 | M9863/3 |
| Methods | qPCR, western blot, RNAi etc. |
| Sample | chronic myeloid leukemia tissues, cell lines (KCL22 and K562) |
| Expression Pattern | down-regulated |
| Function Description | We found that MEG3 and PTEN expression were downregulated, whereas, MDM2, DNMT1 and miR-21 were up-regulated in the accelerated and blast phases of CML. demethylation drugs might also have potential clinical application in treating CML blast crisis. Due to the effect on MEG3 and miR-21, 5-azacytidine may be a possible new therapeutic option for CML blast crisis |
| Pubmed ID | 29772439 |
| Year | 2018 |
| Title | Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21 |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for chronic myeloid leukemia | Omim Cosmic |
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