Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 M8005/0 |
| Methods | Microarray, qPCR, Cell proliferation assay, luciferase reporter assay, etc. |
| Sample | Human proximal tubule epithelial cell line (HKâ??2) . Human CCRCC cell lines (Aâ??498, 786â??O). All clinical human CCRCC samples, normal tissues. |
| Expression Pattern | up-regulated |
| Function Description | In summary, MEG3 could enforce the expression of RASL11B to inhibit the progression of CCRCC by down-regulating miR-7. Through a range of experiments, we verified that overexpressed MEG3 could up-regulate the expression of RASL11B by inhibiting miR-7, suppressing the cell proliferation, migration, and invasion as well as improving apoptosis in CCRCC.MEG3 could up-regulate RASL11B to inhibit the cell proliferation, invasion, and migration; induce G0/G1 cell cycle arrest; and promote cell apoptosis by suppressing miR-7 in CCRCC. |
| Pubmed ID | 29968912 |
| Year | 2018 |
| Title | Study on the mechanism behind lncRNA MEG3 affecting clear cell renal cell carcinoma by regulating miR-7/RASL11B signaling. |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for clear cell renal cell carcinoma | Omim Cosmic |
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