Detail
| LncRNA Name | MEG3 |
| Synonyms | MEG3, FP504, GTL2, LINC00023, NCRNA00023, PRO0518, PRO2160, onco-lncRNA-83, prebp1 |
| Region | GRCh38_14:100779410-100861031 Sequence |
| Ensembl | ENSG00000214548 |
| RefSeq | NR_002766 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, Flow cytometry, etc. |
| Sample | bladder cancer tissues, cell lines (T24, 5637) |
| Expression Pattern | down-regulated |
| Function Description | MEG3 overexpression sensitized BC cells to the chemotherapy drug cisplatin (DDP).MEG3 and p53 could stimulate the expression of each other in BC cells, indicating a potential positive feedback loop of MEG3 and p53.Our data showed that the BC cells overexpressing MEG3 displayed weaker migration and invasion ability than the control cells. |
| Pubmed ID | 29940769 |
| Year | 2018 |
| Title | Up-regulation of LncRNA MEG3 inhibits cell migration and invasion and enhances cisplatin chemosensitivity of bladder cancer cells |
| External Links |
| Links for MEG3 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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