Detail
| LncRNA Name | MIAT |
| Synonyms | MIAT, C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT, FLJ25967 |
| Region | GRCh38_22:26646428-26676475 Sequence |
| Ensembl | ENSG00000225783 |
| RefSeq | NR_003491 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, RNAi etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (HepG2, Huh7, SK-HEP-1, HLE and L02) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of MIAT is related to the proliferation and invasion of HCC,and downregulating MIAT expression inhibited HCC cell proliferation and invasion.The H3/H4 histone acetylation level of MIAT promoter in HCC tissues was higher than that in normal tissues.MIAT negatively regulated miR-214 in HCC cells. Inhibition of miR-214 reversed the influence of MIAT downregulation on HCC cell proliferation and invasion.In nude mouse xenograft models,downregulation of MIAT markedly suppressed the tumor growth of HCC via releasing miR-214.In conclusion, lncRNA MIAT promotes the proliferation and invasion of HCC cells through sponging miR-214, which brings a novel target for the therapy and prognosis of hepatocellular carcinoma.NEW & NOTEWORTHY This is the first research showing long noncoding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) to have a regulatory effect on hepatocellular carcinoma. |
| Pubmed ID | 29097358 |
| Year | 2018 |
| Title | lncRNA MIAT promotes proliferation and invasion of HCC cells via sponging miR-214. |
| External Links |
| Links for MIAT | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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