Detail
| LncRNA Name | MIAT |
| Synonyms | MIAT, C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT, FLJ25967 |
| Region | GRCh38_22:26646428-26676475 Sequence |
| Ensembl | ENSG00000225783 |
| RefSeq | NR_003491 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✔ |
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | M9823/3 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | CLL tissues, leukemia/lymphoma cell lines |
| Expression Pattern | up-regulated |
| Function Description | MIAT expression was upregulated in breast cancer cell lines and tissues.MIAT acted as a competing endogenous RNA (ceRNA) to regulate the expression of dual specificity phosphatase 7 (DUSP7) by taking up miR-155-5p in breast cancer. There were positive correlation between MIAT and DUSP7 expression in breast cancer patients.MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p in breast cancer. MIAT was specifically up-regulated in the plasma and aqueous humor of cataract patients. |
| Pubmed ID | 27527866 |
| Year | 2016 |
| Title | Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias. |
| External Links |
| Links for MIAT | GenBank HGNC lncrnadb Noncode |
| Links for chronic lymphocytic leukemia | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.