Detail
| LncRNA Name | MIAT |
| Synonyms | MIAT, C22orf35, GOMAFU, LINC00066, NCRNA00066, RNCR2, lncRNA-MIAT, FLJ25967 |
| Region | GRCh38_22:26646428-26676475 Sequence |
| Ensembl | ENSG00000225783 |
| RefSeq | NR_003491 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, in vitro knockdown, RNAi |
| Sample | breast tumor tissues, human breast cancer cells (MCF7, SKBR-3), human prostate cancer cells (PC-3, LNCaP), human brain cancer cells (A-172, U-87), neuroblastoma cell line (SH-SY5Y), human colon cancer cell lines (HT-29, SW48, SW480, SW1116), human stomach cancer cell (AGS), human cervix cell (HELA) and human liver hepatocellular carcinoma cell line (Hep G2) |
| Expression Pattern | up-regulated |
| Function Description | MIAT expression was much higher in high-grade tumors compared to low-grade ones. Unlike P53 positive tumors, MIAT expression was upregulated in ER, PR, Her2 positive tumor tissues. An increase in the expression of mir-302, mir-150, and a decrease in the expression of mir-29c were detected following MIAT silencing. More importantly, knockdown MIAT significantly elevated the expression of p16Ink4A and Cox2, which commitment cellular senescence in breast cancer cells. |
| Pubmed ID | 29345338 |
| Year | 2018 |
| Title | MIAT lncRNA is overexpressed in breast cancer and its inhibition triggers senescence and G1 arrest in MCF7 cell line. |
| External Links |
| Links for MIAT | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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