MIR22HG was significantly downregulated in lung cancer;this decreased expression was associated with poor patient survival. MIR22HG bound and stabilized the YBX1 protein.Silencing of MIR22HG triggered both cell survival and cell death signaling through dysregulation of the oncogenes YBX1,MET,and p21. In this MIR22HG network,p21 played an oncogenic role by promoting cell proliferation and anti-apoptosis in lung cancers.MIR22HG played a tumor suppressor role as indicated by inhibition of multiple cell cycle-related genes in human primary lung tumors.