Detail
| LncRNA Name | MNX1-AS1 |
| Synonyms | MNX1-AS1, CCAT5, CCAT5, LOC645249 |
| Region | GRCh38_7:157010805-157016426 Sequence |
| Ensembl | ENSG00000243479 |
| RefSeq | NR_038835 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | qPCR etc. |
| Sample | glioblastoma tissues, cell lines (U138, LN229, T98 and U251) |
| Expression Pattern | up-regulated |
| Function Description | the expression of MNX1-AS1 was significantly upregulated in GBM tissues and cell lines.Knockdown of MNX1-AS1 significantly inhibited the proliferation,migration and invasion of GBM cells. In terms of mechanism,we found that MNX1-AS1 could bind to miR-4443 in GBM cells.Overexpression of miR-4443 significantly inhibited the expression of MNX1-AS1, and vice versa. Moreover,there was an inverse correlation between the expression levels of MNX1-AS1 and miR-4443 in GBM tissues. Moreover,we found that overexpression of miR-4443 inhibited the proliferation, migration and invasion of GBM cells. Besides,we showed that inhibition of miR-4443 reversed the effects of MNX1-AS1 knockdown on GBM cell proliferation, migration and invasion. |
| Pubmed ID | 29678219 |
| Year | 2018 |
| Title | LncRNA MNX1-AS1 promotes glioblastoma progression through inhibition of miR-4443. |
| External Links |
| Links for MNX1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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