Detail
| LncRNA Name | MNX1-AS1 |
| Synonyms | MNX1-AS1, CCAT5, CCAT5, LOC645249 |
| Region | GRCh38_7:157010805-157016426 Sequence |
| Ensembl | ENSG00000243479 |
| RefSeq | NR_038835 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | microarray, qPCR, Luciferase reporter assay etc. |
| Sample | CRC tissues, cell lines (HCT116, RKO, HT29, SW620 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Of the seletced lncRNAs, four lncRNAs named CCAT3, CCAT4, CCAT5, and CCAT6 (also named MYCLo-2) are upregulated in CRC cell lines, and two lncRNAs named CCAT7 and CCAT8 are downregulated in CRC cell lines. MYC-regulated lncRNAs, named MYCLos. The MYC-regulated MYCLos may function in cell proliferation and cell cycle by regulating MYC target genes such as CDKN1A (p21) and CDKN2B (p15), suggesting new regulatory mechanisms of MYC-repressed target genes through lncRNAs. |
| Pubmed ID | 25663692 |
| Year | 2015 |
| Title | Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis. |
| External Links |
| Links for MNX1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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