Detail
| LncRNA Name | AWPPH |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, RIP, ChIP etc. |
| Sample | HCC tissues, cell lines (QSG-7701, SMMC-7721, HCCLM3, Huh7, HepG2, QSG-7701 and SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | High AWPPH expression is an independent prognostic factor for poor recurrence-free and overall survival. AWPPH promotes HCC cell proliferation and migration in vitro, and tumor growth and metastasis in vivo. AWPPH interacts with YBX1, promotes YBX1-mediated activation of SNAIL1 translation, and upregulates SNAIL1 expression.To identify lncRNAs involved in the progression and prognosis of HCC, we analyzed online-available data sets, including GSE54238 (lncRNAs microarray data of 30 noncancerous hepatic tissues and 23 HCC tissues) and GSE40144 (lncRNAs microarray data of 59 HCC tissues with disease-free survival and overall survival information). |
| Pubmed ID | 28428004 |
| Year | 2017 |
| Title | Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker. |
| External Links |
| Links for AWPPH | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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