Detail
| LncRNA Name | MRUL |
| Synonyms | DMTF1, DMP1, DMTF, MRUL, hDMP1 |
| Region | GRCh38_7:87152361-87196337 Sequence |
| Ensembl | ENSG00000135164 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | microarray, qPCR, Western blot etc. |
| Sample | cell line (SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | We show here that the lncRNA MRUL, was significantly upregulated in two multidrug-resistant GC cell sublines, SGC7901/ADR and SGC7901/VCR. Furthermore, the relative expression levels of MRUL in GC tissues were negatively correlated with in vitro growth inhibition rates of GC specimens treated with chemotherapeutic drugs and indicated a poor prognosis for GC patients. MRUL plays a positive role in the regulation of ABCB1 expression and is a potential target to reverse the MDR phenotype of GC MDR cell sublines. |
| Pubmed ID | 24958102 |
| Year | 2014 |
| Title | Long noncoding RNA MRUL promotes ABCB1 expression in multidrug-resistant gastric cancer cell sublines. |
| External Links |
| Links for MRUL | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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