Our data suggests that deficiency or loss of functional mutations of ARID1A in HCC cells might contribute to the increased activity ofcertain cancer-promoting lncRNAsã??AIRD1A fragments (A-1, aa 1e310; A-2, aa 311e600; A-3, aa 601e950; A-4, aa 951e1300; A-5, aa 1301e1600; A-6, aa 1601e1900; A-7, aa 1901e2285) were amplified by PCR and subcloned into pGEX-4T-1 vectors (GE Healthcare Life Sciences) to generate recombinant GST-ARID1A fusion proteins. As a subunit of SWI/SNF complex, ARID1A could contribute to its chromatin remodeling activity by recruiting and binding of specific transcription factor and transcriptional coactivator/corepressor complexes.ARID1A, encoding the BAF250a subunit of SWI/SNF complex, has a high mutation frequency in numerous types of cancer.