Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name AX747207
   Synonyms NA
   Region NA    Sequence
   Ensembl NA
   RefSeq NA
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name breast cancer
   ICD-0-3 C50  
   Methods qPCR etc.
   Sample cell lines (MCF7 and MCF7/ADR)
   Expression Pattern down-regulated
   Function Description

Compared to the MCF-7 cells, 8,892 lncRNAs were differentially expressed in MCF/ADR cells (absolute fold-change >2.0). A total of 32 lncRNAs were selected for RT-qPCR by fold-change filtering, standard Student's t-test, and multiple hypothesis testing. Among the dysregulated lncRNAs, AX747207 was prominent because its associated gene RUNX3 was previously reported to be relative to malignant tumor chemoresistance. In addition, the study identified the lncRNA AX747207, and its potential targeted gene RUNX3, may be related to chemoresistance in breast cancer.

   Pubmed ID 29749447
   Year 2018
   Title Chemoresistance-related long non-coding RNA expression profiles in human breast cancer cells.
   External Links
   Links for  AX747207 GenBank       HGNC       lncrnadb       Noncode
   Links for  breast cancer Omim       Cosmic

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