Detail
| LncRNA Name | MYCNOS-01 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | rhabdomyosarcoma and neuroblastomacells |
| ICD-0-3 | M8900/3 |
| Methods | Microarray, qRT-PCR, Western blot, in vitro knockdown |
| Sample | Human ARMS cell line (RMS-01), cell line (RH30), The human NB cell lines (KELLY and SY5Y) |
| Expression Pattern | up-regulated |
| Function Description | MYCNOS-01 transcript levels were generally higher in NB and RMS tumor samples and cell lines with MYCN genomic amplification. RNA interference of MYCNOS-01 expression did not alter MYCN transcript levels but decreased MYCN protein levels. Conversely, MYCN reduction increased MYCNOS-01 transcript levels,creating a negative feedback loop on MYCN protein levels.Reduction of MYCNOS-01 or MYCN expression decreased cell growth in MYCN-amplified alveolar rhabdomyosarcoma and neuroblastoma cell lines.This is consistent with MYCNOS-01-mediated regulation of MYCN contributing to the phenotype observed.Another possibility therefore is that MYCNOS-01 interacts with an miRNA that targets MYCN for degradation, therefore increasing MYCN protein expression by sequestering away a negative regulating factor. |
| Pubmed ID | 29466962 |
| Year | 2018 |
| Title | The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells. |
| External Links |
| Links for MYCNOS-01 | GenBank HGNC lncrnadb Noncode |
| Links for rhabdomyosarcoma and neuroblastomacells | Omim Cosmic |
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