Detail
| LncRNA Name | NBAT1 |
| Synonyms | NBAT1, CASC14, NBAT-1 |
| Region | GRCh38_6:22134957-22147193 Sequence |
| Ensembl | ENSG00000260455 |
| RefSeq | NR_034143 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✔ |
| Cancer Name | neuroblastoma |
| ICD-0-3 | M9500/3 |
| Methods | qPCR etc. |
| Sample | primary neuroblastoma tissues |
| Expression Pattern | down-regulated |
| Function Description | We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma associated SNP on chromosome 6p22 functionally contribute to NBAT-1 differential expression. Loss of NBAT-1 increases cellular proliferation and invasion. It controls these processes via epigenetic silencing of target genes. NBAT-1 loss affects neuronal differentiation through activation of the neuronal-specific transcription factor NRSF/REST. |
| Pubmed ID | 25517750 |
| Year | 2014 |
| Title | The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation. |
| External Links |
| Links for NBAT1 | GenBank HGNC lncrnadb Noncode |
| Links for neuroblastoma | Omim Cosmic |
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