Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, RNAi, Western blot, RNA pull-down assay, Cell migration and invasion assay etc. |
| Sample | cell lines (CBMs, TAMs, BMDMs, RAW 264.7) |
| Expression Pattern | up-regulated |
| Function Description | NEAT1 was highly expressed in patients with thyroid cancer. NEAT1 knockout inhibited thyroid cancer cell survival, migration and invasion, along with reduced B-catenin (a direct target of miRNA-214) protein expression. Furthermore, NEAT1 significantly accelerated thyroid cancer cell growth and metastasis in vitro and increased tumor size in vivo. Upregulation of NEAT1 decreased the expression of miRNA-214, presenting a reciprocal repression correlation. |
| Pubmed ID | 28000845 |
| Year | 2016 |
| Title | Long non-coding RNA NEAT1 promotes malignant progression of thyroid carcinoma by regulating miRNA-214. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for thyroid cancer | Omim Cosmic |
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