Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | acute promyelocytic leukemia |
| ICD-0-3 | M9866/3 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (NB4 and 293T) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we performed chromatin immunoprecipitation and luciferase reporter assays to demonstrate that C/EBP family transcription factor C/EBPB bind to and transactivate the promoter of lncRNA NEAT1 through the C/EBPB binding sites both around -54 bp and -1453 bp upstream of the transcription start site. Moreover, the expression of C/EBPB was increased after ATRA treatment, and the binding of C/EBPB in the NEAT1 promoter was also dramatically increased. Finally, knockdown of C/EBPB significantly reduced the ATRA-induced upregulation of NEAT1. In conclusion, C/EBPB directly activates the expression of NEAT1 through binding to the promoter of NEAT1. Knockdown of C/EBPB impairs ATRA-induced transcriptional activation of NEAT1. |
| Pubmed ID | 29111326 |
| Year | 2018 |
| Title | C/EBPB contributes to transcriptional activation of long non-coding RNA NEAT1 during APL cell differentiation. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for acute promyelocytic leukemia | Omim Cosmic |
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