Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 M8005/0 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, CCK-8 assay etc. |
| Sample | ccRCC tissues, cell lines (Caki-1, Caki-2, 786-O and ACHN) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of NEAT1 was up-regulated in ccRCC tissues. NEAT1 knock-down suppressed cell proliferation and induced cell apoptosis in ccRCC cell lines. In addition, NEAT1 knock-down suppressed cell invasion and migration and inhibited the mRNA and protein expression levels of epithelial-mesenchymal transition-related markers in ccRCC cell lines. |
| Pubmed ID | 28269753 |
| Year | 2017 |
| Title | LncRNA, NEAT1 is a prognosis biomarker and regulates cancer progression via epithelial-mesenchymal transition in clear cell renal cell carcinoma. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for clear cell renal cell carcinoma | Omim Cosmic |
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