Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 M8070/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (SCC-9,SCC-25, HN4, Tca-8113,Cal-27), OSCC tissues |
| Expression Pattern | up-regulated |
| Function Description | Functionally,knockdown of NEAT1 significantly inhibited cell proliferation and invasion and induced cell cycle arrest at the G0/G1 phase and apoptosis, whereas inhibition of miR-365 abolished the suppressive effect of NEAT1 knockdown on cellular processes. RGS20, a direct target of miR-365, could reverse the tumor suppressive role of miR-365 mimic by enhancing cell viability and motility. Moreover, the protein levels of RGS20, cyclin D1, E-cadherin, N-cadherin and vimentin could be regulated by the NEAT1/miR-365 axis.NEAT1 silencing also inhibited tumor growth in vivo. NEAT1/miR-365/RGS20 axis may be a novel mechanism or therapeutic strategy for OSCC treatment. |
| Pubmed ID | 29484420 |
| Year | 2018 |
| Title | lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR-365/RGS20 in oral squamous cell carcinoma. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for oral squamous cell carcinoma | Omim Cosmic |
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