Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown |
| Sample | cervical cancer specimens tissues, Cervical cancer cell lines (SiHa, Caski, HeLa) |
| Expression Pattern | up-regulated |
| Function Description | the expression of NEAT1 was higher in cervical cancer cells/tissues compared with that in normal human keratinocytes/tissues.downregulation of NEAT1 inhibited colony formation, cell migration and invasion. Further investigation using the luciferase reporter assay revealed that the expression of mircoRNA-101 (miR-101) target gene Fos was positively associated with NEAT1 expression due to NEAT1-competitive molecular sequestering of miR-101 via base pairing. Furthermore, reduction of miR-101 expression by inhibitor transfection reversed the effect of NEAT1 siRNA on cervical cancer cells. |
| Pubmed ID | 29207151 |
| Year | 2017 |
| Title | Long non-coding nuclear paraspeckle assembly transcript 1 acts as prognosis biomarker and increases cell growth and invasion in cervical cancer by sequestering microRNA-101. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
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