Detail
| LncRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 Sequence |
| Ensembl | ENSG00000278910 |
| RefSeq | NR_047671 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | Western blot |
| Sample | PTC tissues, adjacent normal tissues, thyroid cancer cell lines (WRO, CAL-62, BCPAP and FTC-133.) |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of BANCR promoted the migration and invasion of BCPAP cells. Additionally, BANCR mediated epithelial-mesenchymal transition (EMT) by regulating the expression of epithelial (E)-cadherin, vimentin and neuronal (N)-cadherin. Overexpression of BANCR in BCPAP cells decreased the expression of E-cadherin and increased the expression of vimentin, N-cadherin, phospho (p)-c-Raf, p-extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MEK)1/2 and p-ERK1/2. Administration of U0126 inhibitor inhibited the regulation of phosphorylation levels by MEK1/2 and ERK1/2. Additionally, U0126 upregulated the expression of E-cadherin and downregulated the expression of vimentin. BANCR induces EMT in PTC through the Raf/MEK/ERK signaling pathway. |
| Pubmed ID | 29552216 |
| Year | 2018 |
| Title | lncRNA BANCR promotes EMT in PTC via the Raf/MEK/ERK signaling pathway. |
| External Links |
| Links for BANCR | GenBank HGNC lncrnadb Noncode |
| Links for thyroid cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.